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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク AnkB F-Box ： ウィキペディア英語版 AnkB F-Box AnkB F-Box is a protein excreted by ''Legionella pneumophila'' which contains a domain F-box. F-box proteins are involved in the ubiquitination of proteins targeted for degradation by the proteasome. AnkB F-box is a protein that assembles host cell polyubiquitinated proteins on the cytoplasmatic side of Legionella containing vacuole (LCV).〔Christopher T. D. Price, Tasneem Al-Quadan, Marina Santic, Ilan Rosenshine, Yousef Abu Kwaik. Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth. SCIENCE VOL 334 16 DECEMBER 2011〕 This effector is required for intracellular proliferation within human and amoeba cells and for intrapulmonary Legionella proliferation in mice. The presence of the F-box domain is an example of molecular mimicry of eukaryotic F-box by which Legionella exploits the proteasomal degradation capacity of the host cell for its own sake.〔Price C. T., Al-Khodor S., Al-Quadan T., Santic M., Habyarimana F., Kalia A., Kwaik Y. A. (2009). Molecular mimicry by an F-Box Effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa. PLoS Pathog. 5, e1000704. doi: 10.1371/journal.ppat.1000704.〕 == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AnkB F-Box」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.